Differential regulation of Bcl-2 and Bax expression in cells infected with virulent and nonvirulent strains of Sindbis virus

被引：9

作者：

Appel, E

Katzoff, A

Ben-Moshe, T

Kazimirsky, G

Kobiler, D

Lustig, S

Brodie, C ^{[1
]}

机构：

[1] Bar Ilan Univ, Fac Life Sci, IL-52900 Ramat Gan, Israel

[2] Israel Inst Biol Res, Dept Infect Dis, IL-70450 Ness Ziona, Israel

来源：

VIROLOGY | 2000年 / 276卷 / 02期

基金：

以色列科学基金会;

关键词：

D O I：

10.1006/viro.2000.0458

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Sindbis virus is an alphavirus that infects cells in either lyric or persistent infection. In this study we examined the effects of Sindbis virus on cell apoptosis and on the expression of Bcl-2 and Bax. Of the two strains studied, SVA and SVNI, only the neurovirulent strain, SVNI, induced apoptosis of astrocytes and PC-12 cells. SVA, which infects cells in a persistent manner, induced up-regulation of bcl-2 mRNA and Bcl-2 protein, whereas SVNI induced an increase in Bax levels. Our results indicate a differential regulation of Bcl2 and Bax expression by SVA and SVNI, which may be associated with the apoptotic potential Of the viruses. (C) 2000 Academic Press.

引用

页码：238 / 242

页数：5

共 23 条

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