Glycolipids from sponges.: 6.: Plakoside A and B, two unique prenylated glycosphingolipids with immunosuppressive activity from the marine sponge Plakortis simplex

被引：81

作者：

Costantino, V ^{[1
]}

Fattorusso, E ^{[1
]}

Mangoni, A ^{[1
]}

Di Rosa, M ^{[1
]}

Ianaro, A ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat & Farmacol Sperime, I-80131 Naples, Italy

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1997年 / 119卷 / 51期

关键词：

D O I：

10.1021/ja9727225

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Plakoside A (la) and B (29), two unique glycosphingolipids belonging to a new class of prenylated glycolipid, have been isolated from the marine sponge Plakortis simplex, and their structures have been determined by spectroscopic and chemical means. Plakosides are strongly immunosuppressive on activated T cells and proved to be useful natural models for an improved comprehension of the structural requirements for immunomodulating activity of glycosphingolipids.

引用

页码：12465 / 12470

页数：6

共 17 条

[1]

CAFIERI F, 1995, LIEBIGS ANN, P1477

[2]

Cafieri F, 1996, GAZZ CHIM ITAL, V126, P711

[3]

CAFIERI F, 1994, LIEBIGS ANN CHEM, P1186

[4] AN UNUSUAL ETHER GLYCOLIPID FROM THE SENEGALESE SPONGE TRIKENTRION-LOEVE CARTER [J].