Growth hormone and ageing

被引：12

作者：

Johannsson, G ^{[1
]}

Svensson, J ^{[1
]}

Bengtsson, BÅ ^{[1
]}

机构：

[1] Sahlgrens Univ Hosp, Res Ctr Endocrinol & Metab, SE-41345 Gothenburg, Sweden

来源：

GROWTH HORMONE & IGF RESEARCH | 2000年 / 10卷

关键词：

ageing; body composition; growth hormone; growth hormone secretagogue; insulin sensitivity; muscle strength;

D O I：

10.1016/S1096-6374(00)80006-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The proportion of elderly people is steadily growing in Western societies. The result is a disproportionate accumulation of the oldest and most vulnerable sector of the population, suffering from frailty-associated disorders and cardiovascular diseases. Growth hormone (GH) secretion declines progressively during adulthood. In ageing and severe GH deficiency, an individual's muscle mass, muscle strength and bone mass are decreased, and the relative proportion of total and visceral fat is increased. An association between reduced GH levels and the catabolism of ageing has been suggested. GH or GH secretagogue treatment could be of value to minimize the health-related consequences associated with the ageing process. (C) 2000 Harcourt Publishers Ltd.

引用

页码：25 / 30

页数：6

共 59 条

[1] BODY-COMPOSITION, BONE METABOLISM, AND HEART STRUCTURE AND FUNCTION IN GROWTH-HORMONE (GH)DEFICIENT ADULTS BEFORE AND AFTER GH REPLACEMENT THERAPY AT LOW-DOSES [J].

AMATO, G ;

CARELLA, C ;

FAZIO, S ;

LAMONTAGNA, G ;

CITTADINI, A ;

SABATINI, D ;

MARCIANOMONE, C ;

SACCA, L ;

BELLASTELLA, A .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 77 (06) :1671-1676

[2]

Angelin Bo, 1994, Current Opinion in Lipidology, V5, P160, DOI 10.1097/00041433-199405030-00002

[3] The IGF-I response to very low rhGH doses is preserved in human ageing [J].

Arvat, E ;

Ceda, G ;

Ramunni, J ;

Lanfranco, F ;

Aimaretti, G ;

Gianotti, L ;

Broglio, F ;

Ghigo, E .

CLINICAL ENDOCRINOLOGY, 1998, 49 (06) :757-763

[4] Effect of growth-hormone therapy on early atherosclerotic changes in GH-deficient adults [J].

Bengtsson, BA ;

Johannsson, G .

LANCET, 1999, 353 (9168) :1898-1899

[5] TREATMENT OF ADULTS WITH GROWTH-HORMONE (GH) DEFICIENCY WITH RECOMBINANT HUMAN GH [J].

BENGTSSON, BA ;

EDEN, S ;

LONN, L ;

KVIST, H ;

STOKLAND, A ;

LINDSTEDT, G ;

BOSAEUS, I ;

TOLLI, J ;

SJOSTROM, L ;

ISAKSSON, OGP .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 76 (02) :309-317

[6] Nitric oxide may mediate the hemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency - A double-blind, placebo-controlled study [J].

Boger, RH ;

Skamira, C ;

BodeBoger, SM ;

Brabant, G ;

Muhlen, AVZ ;

Frolich, JC .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (12) :2706-2713

[7] METHOD FOR ESTIMATING NUMBER OF MOTOR UNITS IN THENAR MUSCLES AND CHANGES IN MOTOR UNIT COUNT WITH AGING [J].

BROWN, WF .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1972, 35 (06) :845-852

[8] PHYSIOLOGICAL CHANGES IN AGING MUSCLES [J].

CAMPBELL, MJ ;

MCCOMAS, AJ ;

PETITO, F .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1973, 36 (02) :174-182

[9] Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A review [J].

Carroll, PV ;

Christ, ER .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (02) :382-395

[10] Effect of aging on the sensitivity of growth hormone secretion to insulin-like growth factor-I negative feedback [J].

Chapman, IM ;

Hartman, ML ;

Pezzoli, SS ;

Harrell, FE ;

Hintz, RL ;

Alberti, KGMM ;

Thorner, MO .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (09) :2996-3004

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