Acquired T-helper 1 lymphocyte anergy following infection with Mycobacterium ulcerans

被引：44

作者：

Gooding, TM

Kemp, AS

Robins-Browne, RM ^{[1
]}

Smith, M

Johnson, PDR

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

[2] Univ Melbourne, Dept Paediat, Parkville, Vic 3010, Australia

[3] Murdoch Childrens Res Inst, Parkville, Vic, Australia

[4] Royal Childrens Hosp, Dept Immunol, Parkville, Vic 3052, Australia

[5] Austin & Repatriat Med Ctr, Dept Infect Dis, Heidelberg, Vic, Australia

[6] Mossman Hosp, Mossman, Qld, Australia

来源：

CLINICAL INFECTIOUS DISEASES | 2003年 / 36卷 / 08期

关键词：

D O I：

10.1086/368315

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe a patient with acquired T-helper lymphocyte anergy to mycobacteria following infection with Mycobacterium ulcerans. Before infection, the patient's peripheral blood mononuclear cells responded to in vitro stimulation with M. ulcerans by producing Th1 cytokines, but, after she developed an ulcer, the response was shifted toward production of Th2 cytokines. Immunomodulatory therapy may be an effective intervention for Buruli ulcer.

引用

页码：1076 / 1077

页数：2

共 7 条

[1] IL-10-producing T cells suppress immune responses in anergic tuberculosis patients [J].