Bone metabolism in oxalosis: a single-center study using new imaging techniques and biomarkers

被引：25

作者：

Bacchetta, Justine ^{[1
,2
,3
,4
]}

Fargue, Sonia ^{[1
,3
,4
]}

Boutroy, Stephanie ^{[2
,3
]}

Basmaison, Odile ^{[1
,4
]}

Vilayphiou, Nicolas ^{[2
,3
]}

Plotton, Ingrid ^{[3
,4
,5
]}

Guebre-Egziabher, Fitsum ^{[3
,4
,6
]}

Dohin, Bruno ^{[7
,8
]}

Kohler, Remi ^{[3
,4
,7
]}

Cochat, Pierre ^{[1
,3
,4
]}

机构：

[1] Hop Femme Mere Enfant, Ctr Reference Malad Renales Rares, Serv Nephrol & Rhumatol Pediat, F-69677 Bron, France

[2] INSERM, U831, F-69008 Lyon, France

[3] Univ Lyon, F-69008 Lyon, France

[4] Hosp Civils Lyon, Ctr Hosp Univ CHU Lyon, Lyon, France

[5] Hosp Civils Lyon, Ctr Biol Est, Serv Endocrinol Mol & Malad Rares, Lyon, France

[6] Hop Edouard Herriot, Dept Nephrol, Lyon, France

[7] Hop Femme Mere Enfant, Serv Chirurg Orthoped Pediat, Lyon, France

[8] Univ St Etienne, St Etienne, France

来源：

PEDIATRIC NEPHROLOGY | 2010年 / 25卷 / 06期

关键词：

Bone imaging; Children; FGF23; Primary hyperoxaluria; Skeletal age; PREEMPTIVE LIVER-TRANSPLANTATION; PRIMARY HYPEROXALURIA TYPE-1; OXALATE; DISEASE; CHILDREN;

D O I：

10.1007/s00467-010-1453-x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The deposition of calcium oxalate crystals in the kidney and bone is a hallmark of primary hyperoxaluria type 1 (PH1). We report here an evaluation of the bone status of 12 PH1 children based on bone biomarkers [parathyroid hormone, vitamin D, fibroblast growth factor 23 (FGF23)] and radiological assessments (skeletal age, three-dimensional high-resolution peripheral quantitative computed tomography, HR-pQCT) carried out within the framework of a cross-sectional single-center study. The controls consisted of healthy and children with chronic kidney disease already enrolled in local bone and mineral metabolism studies. The mean age (+/- standard deviation) age of the patients was 99 (+/- 63) months. Six children suffered from fracture. Bone maturation was accelerated in five patients, four of whom were < 5 years. The combination of new imaging techniques and biomarkers highlighted new and unexplained features of PH1: advanced skeletal age in young PH1 patients, increased FGF23 levels and decreased total volumetric bone mineral density with bone microarchitecture alteration.

引用

页码：1081 / 1089

页数：9

共 34 条

[1] Bone Imaging and Chronic Kidney Disease: Will High-Resolution Peripheral Tomography Improve Bone Evaluation and Therapeutic Management? [J].