Discrete models of autocrine cell communication in epithelial layers

被引:38
作者
Pribyl, M
Muratov, CB
Shvartsman, SY [1 ]
机构
[1] Princeton Univ, Dept Chem Engn, Princeton, NJ 08544 USA
[2] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA
[3] New Jersey Inst Technol, Dept Math Sci, Newark, NJ USA
[4] New Jersey Inst Technol, Ctr Appl Math & Stat, Newark, NJ USA
基金
美国国家科学基金会;
关键词
D O I
10.1016/S0006-3495(03)75093-0
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Pattern formation in epithelial layers heavily relies on cell communication by secreted ligands. Whereas the experimentally observed signaling patterns can be visualized at single-cell resolution, a biophysical framework for their interpretation is currently lacking. To this end, we develop a family of discrete models of cell communication in epithelial layers. The models are based on the introduction of cell-to-cell coupling coefficients that characterize the spatial range of intercellular signaling by diffusing ligands. We derive the coupling coefficients as functions of geometric, cellular, and molecular parameters of the ligand transport problem. Using these coupling coefficients, we analyze a nonlinear model of positive feedback between ligand release and binding. In particular, we study criteria of existence of the patterns consisting of clusters of a few signaling cells, as well as the onset of signal propagation. We use our model to interpret recent experimental studies of the EGFR/Rhomboid/Spitz module in Drosophila development.
引用
收藏
页码:3624 / 3635
页数:12
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