In vitro evaluation of synthetic heparin-like conjugates comprising different thrombin binding domains

被引：10

作者：

Basten, JEM ^{[1
]}

Dreef-Tromp, CM ^{[1
]}

de Wijs, B ^{[1
]}

van Boeckel, CAA ^{[1
]}

机构：

[1] NV Organon, Sci Dev Grp, NL-5340 BH Oss, Netherlands

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(98)00196-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The syntheses of several heparin-like glycoconjugates (i.e., 16a-f) containing identical AT III binding domains (ABD) and spacers but different thrombin binding domains (TBDs) are described.(1) Biological activities of conjugates 16a-f indicate that the thrombin inhibitory activity is mainly determined by the charge density of the TBD moiety. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：1201 / 1206

页数：6

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