Apolipoprotein E polymorphism in South African Zulu women with preeclampsia

被引:22
作者
Chikosi, AB
Moodley, J
Pegoraro, RJ
Lanning, PA
Rom, L
机构
[1] Univ Natal, Sch Med, Dept Obstet & Gynaecol, ZA-4013 Congella, South Africa
[2] Univ Natal, Sch Med, UN Pregnancy Hypertens Res Unit, MRC, ZA-4013 Congella, South Africa
[3] Univ Natal, Sch Med, Dept Chem Pathol, ZA-4013 Congella, South Africa
关键词
apoiipoprotein E; risk factor; perinatal outcome; preeclampsia;
D O I
10.1081/PRG-100101992
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objectives: Apolipoprotein E may contribute to the hypertriglyceridemia and consequent endothelial dysfunction of preeclampsia. We carried out a study to determine whether the apolipoprotein E genotype plays any role as a risk factor for preeclampsia in a black South African population with a high incidence of preeclampsia. Design: A descriptive, prospective study design was used. Setting: King Edward VIII Hospital, a tertiary care, referral academic hospital in Durban, South Africa. Patients and Participants: One hundred three South African Zulu women with preeclampsia and 110 healthy normotensive women attending the antenatal clinic were recruited. Main Outcome Measures: The relationship between the apolipoprotein E allele and genotype frequencies to preeclampsia as well as adverse perinatal outcome. Results: The frequencies of epsilon2 and epsilon4 alleles (0.19 and 0.25, respectively) were much higher than those reported in other population groups. However, there was no significant difference in the apolipoprotein E genotype and allele frequencies between the study and the control groups. The epsilon2/2 genotype was associated with increased risk of perinatal death (p = 0.047). Conclusion: The study suggests that, despite the high incidence of both preeclampsia and the epsilon2 and epsilon4 alleles in South African Zulu women, apolipoprotein E genotype does not appear to be a risk factor for preeclampsia in this population.
引用
收藏
页码:309 / 314
页数:6
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