Abnormal production of the tumor necrosis factor inhibitor etanercept and clinical efficacy of tumor in a patient with PAPA syndrome

被引：71

作者：

Cortis, E

De Benedetti, F

Insalaco, A

Cioschi, S

Muratori, F

D'Urbano, LE

Ugazio, AG

机构：

[1] Ospediat Pediat Bambino Gesu, IRCCS, Dept Med, Div Rheumatol, I-00165 Rome, Italy

[2] Ospediat Pediat Bambino Gesu, IRCCS, Lab Rheumatol, I-00165 Rome, Italy

来源：

JOURNAL OF PEDIATRICS | 2004年 / 145卷 / 06期

关键词：

D O I：

10.1016/j.jpeds.2004.08.001

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report a family with pyogenic sterile arthritis, pyoderna and acne syndrome (PAPA). The proband presented several episodes of sterile pyogenic arthritis and became unresponsive to glucocorticoids. After treatment with the tumor necrosis factor inhibitor etanercept, the disease underwent rapid and sustained clinical remission. Production of tumor necrosis factor-a by mononuclear cells of the proband and of the affected relatives was abnormally elevated.

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页码：851 / 855

页数：5

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