Biomarkers for Helicobacter pylori infection and gastroduodenal diseases

被引：10

作者：

Shiota, Seiji ^{[1
]}

Yamaoka, Yoshio ^{[1
,2
,3
]}

机构：

[1] Oita Univ, Fac Med, Dept Environm & Prevent Med, Yufu City, Oita, Japan

[2] Baylor Coll Med, Dept Med Gastroenterol, Houston, TX 77030 USA

[3] Michael Eeast Debakey Vet Affairs Med Ctr, Houston, TX 77030 USA

来源：

BIOMARKERS IN MEDICINE | 2014年 / 8卷 / 09期

基金：

日本学术振兴会; 日本科学技术振兴机构;

关键词：

antibody; biomarkers; Helicobacter pylori; miRNA; CHRONIC ATROPHIC GASTRITIS; SERUM PEPSINOGEN; HIGH PREVALENCE; ANTIBODY TITER; IGG ANTIBODY; MOLECULAR EPIDEMIOLOGY; CAGA SEROPOSITIVITY; DIAGNOSTIC-ACCURACY; VIRULENCE FACTORS; CANCER RISK;

D O I：

10.2217/BMM.14.72

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Helicobacter pylori infection is a major cause of gastric cancer. Although identifying H. pylori infected subjects is the first approach for delineating the high-risk population for gastric cancer, the presence of H. pylori antibodies is not sufficient for gastric cancer screening. Among H. pylori infected subjects, only a minority of infected individuals develop gastric cancer. Serologic markers of H. pylori infection can serve as potential predictors for the development of gastric cancer. Serum or urinary H. pylori antibodies, cytotoxin-associated gene A antibodies, pepsinogen and microRNAs were reported to be associated with precancerous lesions or gastric cancer. In this review, we summarized the utilities and limitations of each strategy.

引用

页码：1127 / 1137

页数：11

共 67 条

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Racial differences in Helicobacter pylori, serum pepsinogen and gastric cancer incidence in an urban Asian population [J].