Influence of scale, stoichiometry and temperature on the synthesis of 2,8-dihalo analogues of Troger's base from the corresponding anilines and paraformaldehyde

被引：40

作者：

Jensen, J ^{[1
]}

Strozyk, M ^{[1
]}

Wärnmark, K ^{[1
]}

机构：

[1] Lund Univ, Dept Chem, SE-22100 Lund, Sweden

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2003年 / 40卷 / 02期

关键词：

D O I：

10.1002/jhet.5570400230

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The yields of 2,8-dihalo analogues of Troger's base in the condensation between 4-haloanilines and paraformaldehyde was found to be highly sensitive to the crucial reaction parameters of scale, stoichiometry and temperature. The reaction conditions were optimized allowing for the semi-large scale synthesis of the 2,8-diiodo- (2) and 2,8-dibromo- (3) analogues, respectively.

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页码：373 / 375

页数：3

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