Suppression of LTP-like plasticity in human motor cortex by the GABAB receptor agonist baclofen

被引：112

作者：

McDonnell, Michelle N.

Orekhov, Yuri

Ziemann, Ulf ^{[1
]}

机构：

[1] Univ Frankfurt, Motor Cortex Lab, Dept Neurol, D-60528 Frankfurt, Germany

[2] Univ Adelaide, Res Ctr Human Movement Control, Adelaide, SA 5005, Australia

来源：

EXPERIMENTAL BRAIN RESEARCH | 2007年 / 180卷 / 01期

关键词：

GABA(B) receptor; baclofen; LTP-like plasticity; paired associative stimulation; transcranial magnetic stimulation; human motor cortex;

D O I：

10.1007/s00221-006-0849-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous experiments in slice preparations revealed that pharmacological activation of GABA(B) receptors down- or up-regulates long-term potentiation (LTP), depending on whether increase of GABA(B) receptor mediated inhibitory postsynaptic potentials or decrease of presynaptic auto-inhibition of GABA(A) receptor mediated inhibition predominates. The effects of GABA(B) receptor activation on LTP in humans in vivo are unknown. Here we show, by using transcranial magnetic stimulation, that the GABA(B) receptor agonist baclofen decreases paired associative stimulation induced LTP-like plasticity in human motor cortex. This suggests that increased GABA(B) mediated inhibitory postsynaptic potentials drive this effect, and that baclofen may have a negative impact on LTP-dependent behavioural processes such as motor learning.

引用

页码：181 / 186

页数：6

共 32 条

[1] DIFFERENT VOLTAGE-DEPENDENT THRESHOLDS FOR INDUCING LONG-TERM DEPRESSION AND LONG-TERM POTENTIATION IN SLICES OF RAT VISUAL-CORTEX [J].