Rising levels of human cytomegalovirus (HCMV) antigenemia during initial antiviral treatment of solid-organ transplant recipients with primary HCMV infection

被引：34

作者：

Gerna, G ^{[1
]}

Zavattoni, M

Percivalle, E

Grossi, P

Torsellini, M

Revello, MG

机构：

[1] Policlin San Matteo, IRCCS, Serv Virol, Viral Diagnost Serv, I-27100 Pavia, Italy

[2] Univ Pavia, Inst Infect Dis, I-27100 Pavia, Italy

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 1998年 / 36卷 / 04期

关键词：

D O I：

10.1128/JCM.36.4.1113-1116.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In 7 of 18 solid-organ transplant recipients with primary human cytomegalovirus (HCMV) infection, HCMV antigenemia levels were unexpectedly found to rise significantly (P = 0.018) during a mean time of 7.3 +/- 3.2 days after initiation of specific antiviral treatment, whereas corresponding levels of viremia dropped significantly (P = 0.043). Thus, shifting to an alternative antiviral drug based solely on increasing antigenemia levels is not justified in this group of patients.

引用

页码：1113 / 1116

页数：4

共 17 条

[1] Cytomegalovirus pp65 antigenemia-guided early treatment with ganciclovir versus ganciclovir at engraftment after allogeneic marrow transplantation: A randomized double-blind study [J].

Boeckh, M ;

Gooley, TA ;

Myerson, D ;

Cunningham, T ;

Schoch, G ;

Bowden, RA .

BLOOD, 1996, 88 (10) :4063-4071

[2]

BOLVIN G, 1995, J VIROL METHODS, V51, P329

[3] QUANTIFICATION OF HUMAN CYTOMEGALOVIRUS DNA USING THE POLYMERASE CHAIN-REACTION [J].

FOX, JC ;

GRIFFITHS, PD ;

EMERY, VC .

JOURNAL OF GENERAL VIROLOGY, 1992, 73 :2405-2408

[4]

Gerna G, 1993, Clin Diagn Virol, V1, P47, DOI 10.1016/0928-0197(93)90033-2

[5] HUMAN CYTOMEGALOVIRUS-INFECTION OF THE MAJOR LEUKOCYTE SUBPOPULATIONS AND EVIDENCE FOR INITIAL VIRAL REPLICATION IN POLYMORPHONUCLEAR LEUKOCYTES FROM VIREMIC PATIENTS [J].

GERNA, G ;

ZIPETO, D ;

PERCIVALLE, E ;

PAREA, M ;

REVELLO, MG ;

MACCARIO, R ;

PERI, G ;

MILANESI, G .

JOURNAL OF INFECTIOUS DISEASES, 1992, 166 (06) :1236-1244

[6] QUANTIFICATION OF HUMAN CYTOMEGALOVIRUS VIREMIA BY USING MONOCLONAL-ANTIBODIES TO DIFFERENT VIRAL-PROTEINS [J].

GERNA, G ;

REVELLO, MG ;

PERCIVALLE, E ;

ZAVATTONI, M ;

PAREA, M ;

BATTAGLIA, M .

JOURNAL OF CLINICAL MICROBIOLOGY, 1990, 28 (12) :2681-2688

[7] COMPARISON OF DIFFERENT IMMUNOSTAINING TECHNIQUES AND MONOCLONAL-ANTIBODIES TO THE LOWER MATRIX PHOSPHOPROTEIN (PP65) FOR OPTIMAL QUANTITATION OF HUMAN CYTOMEGALOVIRUS ANTIGENEMIA [J].

GERNA, G ;

REVELLO, MG ;

PERCIVALLE, E ;

MORINI, F .

JOURNAL OF CLINICAL MICROBIOLOGY, 1992, 30 (05) :1232-1237

[8] COMPARATIVE QUANTITATION OF HUMAN CYTOMEGALOVIRUS DNA IN BLOOD LEUKOCYTES AND PLASMA OF TRANSPLANT AND AIDS PATIENTS [J].

GERNA, G ;

FURIONE, M ;

BALDANTI, F ;

SARASINI, A .

JOURNAL OF CLINICAL MICROBIOLOGY, 1994, 32 (11) :2709-2717

[9]

GROSSI P, 1995, TRANSPLANTATION, V59, P847

[10] Guidance of ganciclovir therapy with pp65 antigenemia in cytomegalovirus-free recipients of livers from seropositive donors [J].

Grossi, P ;

Kusne, S ;

Rinaldo, C ;

StGeorge, K ;

Magnone, M ;

Rakela, J ;

Fung, J ;

Starzl, TE .

TRANSPLANTATION, 1996, 61 (11) :1659-1660

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