Localization and stabilization of ionotropic glutamate receptors at synapses

被引:19
作者
Bolton, MM [1 ]
Blanpied, TA [1 ]
Ehlers, MD [1 ]
机构
[1] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA
关键词
glutamate receptor; synapse; membrane targeting; plasticity; synaptic transmission; synaptogenesis; cytoskeleton;
D O I
10.1007/PL00000636
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Appropriate targeting and clustering of ionotropic glutamate receptors (iGluRs) is critical for the formation and maintenance of excitatory synapses. Recent studies have demonstrated that the synaptic localization of iGluR subtypes is remarkably heterogeneous and subject to regulation over time scales ranging from minutes to months. These findings, together with the identification of key protein binding partners of iGluRs, have opened a window onto the complex cell biology of iGluR membrane trafficking. In this article, we review recent findings on the cellular and molecular mechanisms involved in localizing iGluRs at synapses and discuss their implications for synaptogenesis and synaptic plasticity.
引用
收藏
页码:1517 / 1525
页数:9
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