Genetic diversity of pneumococcal surface protein A of Streptococcus pneumoniae meningitis in German children

被引：20

作者：

Heeg, Christiane ^{[1
]}

Franken, Carmen ^{[1
]}

van der Linden, Mark ^{[1
]}

Al-Lahham, Adnan ^{[1
]}

Reinert, Ralf Rene ^{[1
]}

机构：

[1] Univ Hosp, Inst Med Microbiol, Natl Reference Ctr Streptococci, Rhein Westfal TH Aachen, D-52057 Aachen, Germany

来源：

VACCINE | 2007年 / 25卷 / 06期

关键词：

epidemiology; PspA; vaccine; pneumococcal; Streptococcus pneumoniae;

D O I：

10.1016/j.vaccine.2006.09.061

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pneumococcal surface protein A (PspA) is a possible candidate for the development of a pneumococcal vaccine that has the potential to offer a broad range of protection. PspA genes of pneumococcal meningitis isolates (n = 40) isolated as part of an ongoing population-based nation-wide surveillance program on invasive pneumococcal disease in children in Germany were analyzed to expand our knowledge on the distribution of PspA families of this important vaccine candidate in Germany. The serotype distribution of the strains was as follows: serotype 4 (n = 3), 6B (5), 9V (2), 14 (8), 18C (6), 19F (5), 23F (6), and 7F (5). The pspA genes of these strains could be assigned to 2 families containing 20 pneumococcal strains each. Family I could be subdivided into 2 clades with 17 strains in clade 1 and 3 strains in clade 2, and family 11 could be subdivided into 3 subgroups (clades 3-5) containing 16, 3, and I strain, respectively. Pneumococcal serotypes were distributed evenly over all clades and families. Interestingly, the distribution of the PspA gene families in Germany was seen to differ slightly that found in other countries. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1030 / 1035

页数：6

共 22 条

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