Drug use and medication adherence among HIV-1 infected individuals

被引：244

作者：

Hinkin, Charles H.

Barclay, Terry R.

Castellon, Steven A.

Levine, Andrew J.

Durvasula, Ramani S.

Marion, Sarah D.

Myers, Hector F.

Longshore, Douglas

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90024 USA

[2] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA

[3] Calif State Univ Los Angeles, Los Angeles, CA 90032 USA

[4] Point Loma Univ, San Diego, CA USA

[5] Charles R Drew Univ Med & Sci, Res Ctr Ethn Hlth & Behav, Los Angeles, CA 90059 USA

来源：

AIDS AND BEHAVIOR | 2007年 / 11卷 / 02期

关键词：

HIV infection; AIDS; medication adherence; drug use; methamphetamine; cocaine;

D O I：

10.1007/s10461-006-9152-0

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This longitudinal study examined the impact of drug use and abuse on medication adherence among 150 HIV-infected individuals, 102 who tested urinalysis positive for recent illicit drug use. Medication adherence was tracked over a 6-month period using an electronic monitoring device (MEMS caps). Over the 6-month study drug-positive participants demonstrated significantly worse medication adherence than did drug-negative participants (63 vs. 79%, respectively). Logistic regression revealed that drug use was associated with over a fourfold greater risk of adherence failure. Stimulant users were at greatest risk for poor adherence. Based upon within-participants analyses comparing 3-day adherence rates when actively using versus not using drugs, this appears to be more a function of state rather than trait. These data suggest that it is the acute effects of intoxication, rather than stable features that may be characteristic of the drug-using populace, which leads to difficulties with medication adherence.

引用

页码：185 / 194

页数：10

共 58 条

[1] Impact of active drug use on antiretroviral therapy adherence and viral suppression in HIV-infected drug users [J].