Loss of Raf-1 kinase inhibitor protein expression is associated with tumor progression and metastasis in colorectal cancer

被引：98

作者：

Minoo, Parham

Zlobec, Inti

Baker, Kristi

Tornillo, Luigi

Terracciano, Luigi

Jass, Jeremy R.

Lugli, Alessandro

机构：

[1] McGill Univ, Dept Pathol, Montreal, PQ H3A 2B4, Canada

[2] Univ Basel Hosp, Inst Pathol, CH-4031 Basel, Switzerland

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2007年 / 127卷 / 05期

关键词：

colorectal cancer; Raf-1 kinase inhibitor protein; RKIP; prognosis; tissue microarray; immunohistochemistry; apoptosis; metastasis;

D O I：

10.1309/5D7MM22DAVGDT1R8

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Raf-1 kinase inhibitor protein (RKIP) is known as a critical down-regulator of the mitogen-activated protein kinase signaling pathway and a potential molecular determinant of malignant metastasis. The aim of this study was to determine the prognostic significance of RKIP expression in colorectal cancer (CRC). Immunohistochemical staining for RKIP was performed on a tissue microarray comprising 1, 197 mismatch repair (MMR)-proficient and 141 MMR-deficient CRCs. The association of RKIP with clinicopathologic features was analyzed. Loss of cytoplasmic RKIP was associated with distant metastasis (P = .038), higher N stage (P = .032), vascular invasion (P = .01), and worse survival (P = .001) in the MMR-proficient group. In MMR-deficient CRCs, loss of cytoplasmic RKIP was associated with distant metastasis (P = .043) and independently predicted worse survival (P = .004). Methylation analysis of 28 cases showed that loss of RKIP expression is unlikely to be due to promoter methylation. Loss of RKIP expression is a marker of tumor progression and distant metastasis in MMR-proficient and MMR-deficient CRCs.

引用

页码：820 / 827

页数：8

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