New antiproliferative epoxysecosterols from Pseudopterogorgia americana

被引：29

作者：

Naz, S

Kerr, RG

Narayanan, R

机构：

[1] Florida Atlantic Univ, Ctr Mol Biol & Biotechnol, Dept Chem & Biochem, Boca Raton, FL 33431 USA

[2] Florida Atlantic Univ, Ctr Mol Biol & Biotechnol, Dept Biol Sci, Boca Raton, FL 33431 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 32期

关键词：

NMR; mass spectrometery; steroids; anti-tumor compounds and anti-inflammatory compounds;

D O I：

10.1016/S0040-4039(00)01015-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new 9(11)-secogorgosterols containing oxirane rings at the C-5/C-6 position (1 and 2) were isolated from Pseudopterogorgia americana along with a known secogorgosterol (3). The structures were elucidated using detailed spectroscopic studies and the epoxysecosteroids were found to exhibit activity against prostate (LnCaD) and lung cancer (Calu-3) cell lines. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：6035 / 6040

页数：6

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