Sperm Analysis of Patients After Successful Treatment of Childhood Acute Lymphoblastic Leukemia With Chemotherapy

被引：10

作者：

Marquis, Adine ^{[1
]}

Kuehni, Claudia E. ^{[1
]}

Strippoli, Marie-Pierre F. ^{[1
]}

Kuehne, Thomas ^{[2
]}

Brazzola, Pierluigi ^{[3
]}

机构：

[1] Univ Bern, Inst Social & Prevent Med, Swiss Childhood Canc Registry, CH-3012 Bern, Switzerland

[2] Univ Childrens Hosp Basel, Basel, Switzerland

[3] Osped Reg Bellinzona & Valli Bellinzona, Bellinzona, Switzerland

来源：

PEDIATRIC BLOOD & CANCER | 2010年 / 55卷 / 01期

关键词：

ALL; childhood cancer; fertility; CANCER; FERTILITY; SURVIVORS; RISK;

D O I：

10.1002/pbc.22475

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Survivors of childhood acute lymphoblastic leukemia (ALL) treated with radiotherapy are at risk for impaired fertility. Whether chemotherapy alone is also long-term gonadotoxic is unclear. We assessed gonadal function in 11 male ALL-survivors treated with the same chemotherapy regimen and compared sperm analysis to healthy men. While sex hormone levels were normal in all subjects, 5/11 survivors showed pathological sperm concentration and 4/11 a decreased total sperm count compared to WHO criteria. Compared to healthy controls, all quantitative parameters in semen analysis of survivors were decreased. This suggests that treatment with chemotherapeutic agents alone, even in moderate doses, might have a gonadotoxic effect. Pediatr Blood Cancer 2010;55:208-210. (C) 2010 Wiley-Liss, Inc.

引用

页码：208 / 210

页数：3

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