Feeding association between the nucleus of the solitary tract and the ventral tegmental area

被引：9

作者：

Kim, Eun-Mee ^{[2
]}

Quinn, Joseph G. ^{[3
]}

Spanswick, David ^{[4
]}

O'Hare, Eugene ^{[1
]}

机构：

[1] Queens Univ Belfast, Sch Psychol, Belfast BT7 1NN, Antrim, North Ireland

[2] Univ Ulster, Sch Psychol, Coleraine BT52 1SA, Londonderry, North Ireland

[3] Queens Univ Belfast, Sch Biol Sci, Belfast BT7 1NN, Antrim, North Ireland

[4] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England

来源：

APPETITE | 2009年 / 53卷 / 03期

关键词：

Ventral tegmental area; Nucleus of the solitary tract; D-Ala(2); NMe-Phe(4); Gly-ol(5)]-enkaphalin (DAMGO); Naltrexone; Feeding; MU-OPIOID RECEPTORS; CENTRAL-NERVOUS-SYSTEM; FOOD-INTAKE; ACCUMBENS SHELL; PARAVENTRICULAR NUCLEUS; GABA(A) RECEPTORS; MEDIAL NUCLEUS; RAT; LOCALIZATION; ANTAGONISTS;

D O I：

10.1016/j.appet.2009.09.003

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Male Sprague-Dawley rats were fitted with two cannulae in the VTA and one cannula in the NTS for co-administration of the mu-opioid receptoragonist DAMGO in one site and the opioid antagonist naltrexone in the other. Injection of DAMGO into the VTA or the NTS stimulated feeding. The increase in food intake after DAMGO injection into the VTA was decreased following injection of naltrexone into the NTS. Furthermore, the increase in food intake after DAMGO injection into the NTS was decreased following injection of naltrexone into the VTA. These results suggest an opioid-mediated feeding association between the VTA and NTS. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：457 / 460

页数：4

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