Enantioselective Cu-catalyzed conjugate addition of diethylzinc to acyclic aliphatic enones

被引：49

作者：

Duncan, AP ^{[1
]}

Leighton, JL ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 22期

关键词：

D O I：

10.1021/ol048191o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new P-chiral phosphine bis(sulfonamide) ligand has been developed that allows the Cu-catalyzed enantioselective conjugate addition of Et2Zn to acyclic aliphatic enones. The reactions proceed with excellent levels of enantioselectivity (90-95% ee) with a range of enone substrates, involve the use of only 1.2 equiv of Et2Zn, and give best results at ambient temperature.

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页码：4117 / 4119

页数：3

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