Tetracycline-regulated gene expression in the brain

被引：84

作者：

Mansuy, IM ^{[1
]}

Bujard, H

机构：

[1] ETH Honggerberg, Inst Cell Biol, Swiss Fed Inst Technol, CH-8093 Zurich, Switzerland

[2] Heidelberg Univ, Zentrum Mol Biol, D-69120 Heidelberg, Germany

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2000年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0959-4388(00)00127-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The possibility of regulating individual gene activities in the mouse brain via the tetracycline-controlled transcriptional activation systems has sparked the development of novel mouse models aimed at elucidating the molecular mechanisms of brain disorders such as Huntington's, prion and Parkinson's diseases. In the past year, novel experimental strategies and methodological advances have emerged, contributing to the resolution of some of the initial limitations of these regulatory systems.

引用

页码：593 / 596

页数：4

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