Isolation and synthesis of a new bioactive ellagic acid derivative from Combretum yunnanensis

被引：26

作者：

Asami, Y

Ogura, T

Otake, N

Nishimura, T

Yao, XS

Sakurai, T

Nagasawa, H

Sakuda, S ^{[1
]}

Tatsuta, K

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Bunkyo Ku, Tokyo 1138657, Japan

[2] Shenyang Pharmaceut Univ, Dept Nat Prod, Shenyang 110015, Peoples R China

[3] Waseda Univ, Grad Sch Sci & Engn, Shinjuku Ku, Tokyo 1698555, Japan

[4] Teikyo Univ, Sch Sci & Technol, Dept Biosci, Utsunomiya, Tochigi 3208551, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 05期

关键词：

D O I：

10.1021/np030041j

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new ellagic acid derivative (1) was isolated from the branches of Combretum yunnanensis, and its structure was assigned as 4-(4"-O-acetyl-alpha-rhamnopyranosyl)ellagic acid by analysis of its spectral data. Total synthesis of 1 was achieved by the glycosylation of 3,3'-di-O-benzylellagic acid (5) with 4-O-acetyl-2,3-di-O-benzyl-L-rhamnose (4) as a key reaction, and the absolute configuration of I was determined. Compound 1 showed weak inhibitory activity against the growth of various tumor cells and inhibited HIV-1 protease.

引用

页码：729 / 731

页数：3

共 14 条

[1] PLANT POLYPHENOLS .6. EXPERIMENTS ON THE SYNTHESIS OF 3,3'-DI-O-METHYLELLAGIC AND 4,4'-DI-O-METHYLELLAGIC ACID [J].