Anti-diabetic effects of Sutherlandia frutescens in Wistar rats fed a diabetogenic diet

被引：54

作者：

Chadwick, Wayne Anthony

Roux, Saartjie

de Venter, Maryna van

Louw, Johan

Oelofsen, Willem

机构：

[1] Nelson Mandela Metropolitan Univ Port Elizabeth, Dept Biochem & Microbiol, ZA-6031 Port Elizabeth, Eastern Prov, South Africa

[2] MRC, Diabet Res Grp, ZA-7505 Tygerberg, South Africa

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2007年 / 109卷 / 01期

基金：

英国医学研究理事会; 新加坡国家研究基金会;

关键词：

hyperinsulinaemia; insulin resistance; glucose clearance; metformin; Sutherlandia frutescens; diabetogenic;

D O I：

10.1016/j.jep.2006.07.012

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Sutherlandia frutescens has been marked as a potential hypoglycaemic agent for the treatment of type 2 diabetes. We investigated the effects of Sutherlandia frutescens in bringing about hypoglycaemia and promoting glucose uptake in pre-diabetic rats. Crushed Sutherlandia frutescens leaves in drinking water were administered to rats fed a high fat diet. Positive control rats received only metformin. Glucose uptake experiments were undertaken using [H-3] deoxy-glucose. Various physiological parameters were also measured. Rats receiving Sutherlandia frutescens displayed normoinsulinaemic levels, after 8 weeks medicational compliance, compared to the fatty controls. There was a significant increase in glucose uptake into muscle and adipose tissue, and a significant decrease in intestinal glucoseuptake (p < 0.001 at 60 min) in rats receiving the plant extract. The Sutherlandia frutescens plant extract shows promise as a type 2 anti-diabetes medication because of its ability to normalize insulin levels and glucose uptake in peripheral tissues and suppress intestinal glucose uptake, with no weight gain noted. The exact mechanism of action and the extract's efficacy in humans need further confirmation. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：121 / 127

页数：7

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