Estrogen receptor α gene polymorphisms associated with incident aging macula disorder

被引:25
作者
Boekhoorn, Sharmila S.
Vingerling, Johannes R.
Uitterlinden, Andre G.
Van Meurs, Joyce B. J.
van Duijn, Cornelia M.
Pols, Huibert A. P.
Hofman, Albert
de Jong, Paulus T. V. M.
机构
[1] Netherlands Inst Neurosci, KNAW, NL-1105 BA Amsterdam, Netherlands
[2] Erasmus MC, Dept Epidemiol & Biostat, Rotterdam, Netherlands
[3] Erasmus MC, Dept Ophthalmol, Rotterdam, Netherlands
[4] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands
[5] Univ Amsterdam, Acad Med Ctr, Dept Ophthalmol, NL-1105 AZ Amsterdam, Netherlands
关键词
D O I
10.1167/iovs.06-0577
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
PURPOSE. It has been suggested that early menopause increases the risk of aging-macula disorder (AMD), the major cause of incurable blindness with a dry and wet late subtype, and that exposure to endogenous or postmenopausal exogenous estrogens reduces this risk. This study was undertaken to investigate whether genetic variations in the estrogen receptor alpha (ESRI) gene are associated with incident AMD. METHODS. In the Rotterdam Study, a prospective population-based cohort study of participants aged 55 years and older, associations between ESR1 PvuII-XbaI haplotypes and incident early or late AMD were studied in 4571 participants after a mean follow-up time of 7.7 years. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs), with adjustment for the most common confounders. RESULTS. ESR1 PvuII-XbaI haplorype 1 was a risk factor for late AMD. Persons with two copies of haplotype I were at 3.20 (95% CI, 1.47- 6.99) times higher risk for late AMD than noncarriers of haplotype 1, after adjustment for age and sex. This increase was more pronounced for wet AMD (hazard ratio [HR] 4.29; 95% CI, 1.47-12.49) after adjustment for age, sex, smoking, and complement factor H genotype. Correction for additional confounders, including age at menopause, use of hormone replacement therapy, blood pressure, and body mass index did not essentially alter the findings. CONCLUSIONS. Persons with one or two copies of ESRI PvuII-XbaI haplotype I have an increased risk of late AMD, especially of the wet form.
引用
收藏
页码:1012 / 1017
页数:6
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