Mechanisms for synapse specificity during striatal long-term depression

被引：62

作者：

Singla, Sheela

Kreitzer, Anatol C.

Malenka, Robert C.

机构：

[1] Stanford Univ, Med Ctr, Dept Psychiat, Palo Alto, CA 94304 USA

[2] Stanford Univ, Sch Med, Nancy Pritzker Lab, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA

来源：

JOURNAL OF NEUROSCIENCE | 2007年 / 27卷 / 19期

关键词：

endocannabinoid; striatum; synaptic plasticity; basal ganglia; dopamine; LTD;

D O I：

10.1523/JNEUROSCI.0018-07.2007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Endocannabinoid (eCB)-mediated forms of long-term synaptic plasticity occur in several brain regions, but much remains unknown about their basic properties and underlying mechanisms. Here, we present evidence that eCB-mediated long-term depression (eCB-LTD) at excitatory synapses on medium spiny neurons in the striatum requires presynaptic activity coincident with CB1 receptor activation. This dual requirement for CB1 activation and presynaptic activity is a mechanism by which eCB-LTD may be made synapse specific.

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收藏

页码：5260 / 5264

页数：5

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