Palladium-catalyzed enantioselective diboration of prochiral allenes

被引：184

作者：

Pelz, NF

Woodward, AR

Burks, HE

Sieber, JD

Morken, JP ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem, Venable Lab, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Chem, Kenan Lab, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 50期

关键词：

D O I：

10.1021/ja044167u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pd-catalyzed diboration of prochiral allenes occurs exclusively at the internal position and is remarkably accelerated in the presence of Lewis basic ligand structures. On the basis of preliminary observations, a chiral ligand was employed, and the enantiomeric excess of a variety of diboration products was found to be in the range of 86-92% ee. The chiral diboron reaction products should be useful in organic synthesis, and preliminary experiments suggest that they may participate in allylation reactions with a high level of chirality transfer. Copyright © 2004 American Chemical Society.

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页码：16328 / 16329

页数：2

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