Expression of tan immunoreactivity in the spinal motor neurons of Alzheimer's disease

被引：26

作者：

Saito, Y

Murayama, S

机构：

[1] Tokyo Metropolitan Inst Gerontol, Dept Neuropathol, Itabashi Ku, Tokyo 1730015, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Neurol, Div Neurosci, Tokyo, Japan

来源：

NEUROLOGY | 2000年 / 55卷 / 11期

关键词：

D O I：

10.1212/WNL.55.11.1727

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Tau-related pathology was investigated in the spinal cord of 11 patients with AD. Ten ALS and 10 age-matched neurologically intact patients served as controls. Tau immunoreactivity was detected in neurons of the anterior horn in all AD cases and to a lesser extent in the intermediate zone and in the posterior horn. Tau immunoreactivity was rare in controls. Neurofibrillary tangles were identified in seven AD cases, but none was observed in the controls.

引用

收藏

页码：1727 / 1729

页数：3

相关论文

共 11 条

[1] Consensus recommendations for the postmortem diagnosis of Alzheimer's disease [J].

Ball, M ;

Braak, H ;

Coleman, P ;

Dickson, D ;

Duyckaerts, C ;

Gambetti, P ;

Hansen, L ;

Hyman, B ;

Jellinger, K ;

Markesbery, W ;

Perl, D ;

Powers, J ;

Price, J ;

Trojanowski, JQ ;

Wisniewski, H ;

Phelps, C ;

Khachaturian, Z .

NEUROBIOLOGY OF AGING, 1997, 18 (04) :S1-S2

[2] Evaluation of neuronal loss, astrocytosis and abnormalities of cytoskeletal components of large motor neurons in the human anterior horn in aging [J].

Cruz-Sánchez, FF ;

Moral, A ;

Tolosa, E ;

de Belleroche, J ;

Rossi, ML .

JOURNAL OF NEURAL TRANSMISSION, 1998, 105 (6-7) :689-701

[3] MONOCLONAL-ANTIBODY AT8 RECOGNIZES TAU-PROTEIN PHOSPHORYLATED AT BOTH SERINE-202 AND THREONINE-205 [J].

GOEDERT, M ;

JAKES, R ;

VANMECHELEN, E .

NEUROSCIENCE LETTERS, 1995, 189 (03) :167-170

[4]

GROGAN TM, 1993, ADV PATHOLOGY LAB ME, V6, P253

[5] Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform [J].

Ishihara, T ;

Hong, M ;

Zhang, B ;

Nakagawa, Y ;

Lee, MK ;

Trojanowski, JQ ;

Lee, VMY .

NEURON, 1999, 24 (03) :751-762

[6]

Jicha GA, 1997, J NEUROSCI RES, V48, P128, DOI 10.1002/(SICI)1097-4547(19970415)48:2<128::AID-JNR5>3.0.CO

[7]

2-E

[8] SPINAL-CORD LESIONS IN PROGRESSIVE SUPRANUCLEAR PALSY - SOME NEW OBSERVATIONS [J].

KATO, T ;

HIRANO, A ;

WEINBERG, MN ;

JACOBS, AK .

ACTA NEUROPATHOLOGICA, 1986, 71 (1-2) :11-14

[9] SPINAL-CORD NEUROFIBRILLARY TANGLES OF GUAMANIAN AMYOTROPHIC LATERAL SCLEROSIS AND PARKINSONISM-DEMENTIA COMPLEX - AN IMMUNOHISTOCHEMICAL STUDY [J].

MATSUMOTO, S ;

HIRANO, A ;

GOTO, S .

NEUROLOGY, 1990, 40 (06) :975-979

[10]

Spillantini MG, 1998, BRAIN PATHOL, V8, P387