Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease

被引：39

作者：

Brindle, N

Song, Y

Rogaeva, E

Premkumar, S

Levesque, G

Yu, G

Ikeda, M

Nishimura, M

Paterson, A

Sorbi, S

Duara, R

Farrer, L

St George-Hyslop, P

机构：

[1] Univ Toronto, Dept Med, Div Neurol, Ctr Res Neurodegenerat Dis, Toronto, ON M5S 3H2, Canada

[2] Toronto Hosp, Dept Med, Div Neurol, Toronto, ON M5S 3H2, Canada

[3] Boston Univ, Sch Med, Dept Neurol, Neurogenet Lab, Boston, MA 02118 USA

[4] Univ Toronto, Clarke Inst Psychiat, Neurogenet Lab, Toronto, ON, Canada

[5] Dept Neurol & Psychiat, I-50134 Florence, Italy

[6] Mt Sinai Med Ctr, Wein Ctr, Dept Neurol, Miami Beach, FL 33140 USA

来源：

HUMAN MOLECULAR GENETICS | 1998年 / 7卷 / 05期

关键词：

D O I：

10.1093/hmg/7.5.933

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The K-variant of butyrylcholinesterase (BCHE-K) recently has been reported to be associated with Alzheimer disease (AD) in carriers of the epsilon 4 allele of the apolipoprotein E (APOE) gene. We have re-examined the frequency of the BCHE-K allele in a large data set of both sporadic and familial cases of AD disease, and we have also examined the segregation of three genetic markers on chromosome 3 near BCHE. Our data neither support an association of BCHE-K with sporadic or familial AD, nor do they suggest the existence of another gene nearby on chromosome 3 as a common cause of familial AD.

引用

页码：933 / 935

页数：3

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