3D Bioprinting: from Benches to Translational Applications

被引：430

作者：

Heinrich, Marcel Alexander ^{[1
,2
]}

Liu, Wanjun ^{[1
,3
]}

Jimenez, Andrea ^{[1
,4
]}

Yang, Jingzhou ^{[1
,5
]}

Akpek, Ali ^{[1
,6
,7
]}

Liu, Xiao ^{[1
,8
]}

Pi, Qingmeng ^{[1
,9
]}

Mu, Xuan ^{[1
]}

Hu, Ning ^{[1
,10
]}

Schiffelers, Raymond Michel ^{[11
]}

Prakash, Jai ^{[2
]}

Xie, Jingwei ^{[12
]}

Zhang, Yu Shrike ^{[1
]}

机构：

[1] Harvard Med Sch, Dept Med, Brigham & Womens Hosp, Div Engn Med, Cambridge, MA 02139 USA

[2] Univ Twente, Tech Med Ctr, Sect Targeted Therapeut, Dept Biomat Sci & Technol, NL-7500 AE Enschede, Netherlands

[3] Donghua Univ, Coll Text, Key Lab Text Sci & Technol, Shanghai 201620, Peoples R China

[4] Inst Tecnol & Estudios Super Monterrey, Biomed Engn Lab, Monterrey 64849, Nuevo Leon, Mexico

[5] Ctr Biomed Mat 3D Printing, Natl Engn Lab Polymer Complex Struct Addit Mfg, Baoding 071000, Peoples R China

[6] Gebze Tech Univ, Dept Bioengn, TR-41400 Gebze, Turkey

[7] Sabanci Univ, Nanotechnol Res & Applicat Ctr, TR-34956 Tuzla Istanbul, Turkey

[8] Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Sch Biol Sci & Med Engn, Key Lab Biomech & Mechanobiol,Minist Educ, Beijing 100083, Peoples R China

[9] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Plast & Reconstruct Surg, Shanghai 200127, Peoples R China

[10] Zhejiang Univ, Dept Biomed Engn, Biosensor Natl Special Lab, Key Lab Biomed Engn,Educ Minist, Hangzhou 310027, Zhejiang, Peoples R China

[11] Univ Med Ctr Utrecht, Dept Clin Chem & Hematol, NL-3584 CX Utrecht, Netherlands

[12] Univ Nebraska Med Ctr, Holland Regenerat Med Program, Omaha, NE 68198 USA

来源：

SMALL | 2019年 / 15卷 / 23期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

3D bioprinting; additive manufacturing; bioinks; regenerative medicine; tissue engineering; MESENCHYMAL STEM-CELLS; PERIPHERAL-NERVE INJURY; WALLED CARBON NANOTUBES; EXTRACELLULAR-MATRIX; TISSUE CONSTRUCTS; CARTILAGE TISSUE; IN-VITRO; ELECTROSPUN NANOFIBERS; SHAPE TRANSFORMATIONS; COMPOSITE SCAFFOLDS;

D O I：

10.1002/smll.201805510

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Over the last decades, the fabrication of 3D tissues has become commonplace in tissue engineering and regenerative medicine. However, conventional 3D biofabrication techniques such as scaffolding, microengineering, and fiber and cell sheet engineering are limited in their capacity to fabricate complex tissue constructs with the required precision and controllability that is needed to replicate biologically relevant tissues. To this end, 3D bioprinting offers great versatility to fabricate biomimetic, volumetric tissues that are structurally and functionally relevant. It enables precise control of the composition, spatial distribution, and architecture of resulting constructs facilitating the recapitulation of the delicate shapes and structures of targeted organs and tissues. This Review systematically covers the history of bioprinting and the most recent advances in instrumentation and methods. It then focuses on the requirements for bioinks and cells to achieve optimal fabrication of biomimetic constructs. Next, emerging evolutions and future directions of bioprinting are discussed, such as freeform, high-resolution, multimaterial, and 4D bioprinting. Finally, the translational potential of bioprinting and bioprinted tissues of various categories are presented and the Review is concluded by exemplifying commercially available bioprinting platforms.

引用

页数：47

共 316 条

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