Caspase inhibition, specifically

被引：10

作者：

Salvesen, Guy S. ^{[1
]}

Riedl, Stefan J. ^{[1
]}

机构：

[1] Burnham Inst Med Res, Program Apoptosis & Cell Death Res, La Jolla, CA 92037 USA

来源：

STRUCTURE | 2007年 / 15卷 / 05期

关键词：

D O I：

10.1016/j.str.2007.04.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this issue of Structure, Grutter and coworkers report mutagenesis of ankyrin repeat proteins to generate the first specific, tight-binding caspase inhibitor selectively targeting caspase-2 (Schweizer et al., 2007). Interestingly, this inhibitor operates by an allosteric mechanism that does not target the enzyme active site.

引用

页码：513 / 514

页数：2

共 10 条

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