Age-related changes in antioxidant status and oxidative damage to lipids and dna in mitochondria of rat liver

被引：18

作者：

Valls, V

Peiro, C

Muñiz, P

Saez, GT

机构：

[1] Univ Burgos, Fac Ciencias, Area Bioquim & Biol Mol, Burgos 09001, Spain

[2] Univ Valencia, Fac Med, Dpto Pediat Ginecol & Obstet, Valencia, Spain

[3] Univ Valencia, Fac Med, Dpto Bioquim & Biol Mol, Valencia, Spain

来源：

PROCESS BIOCHEMISTRY | 2005年 / 40卷 / 02期

关键词：

antioxidant enzymes; GSH; lipid peroxidation; DNA damage; membrane potential;

D O I：

10.1016/j.procbio.2004.02.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To investigate the correlation between oxidative stress and mitochondrial damage with aging, antioxidant system, levels of oxidative DNA damage and as an index of the loss of plasma membrane integrity lipid peroxidation and membrane potential were studied. Results showed that the activities of antioxidant enzymes superoxide dismutase (SOD) and catalase significantly decreased during aging, however glutathione peroxidase (GSH-PX) increased in the aged mitochondria and glutathione (GSH) did not change during aging. No statistical difference was observed in the lipid peroxidation of mitochondria between young and old animals. The level of oxidative DNA damage (measured as 8oxo-dG) tended to increase during aging. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：903 / 908

页数：6

共 35 条

[1] ASSOCIATION OF A PROTEIN-STRUCTURE OF PROBABLE MEMBRANE DERIVATION WITH HELA-CELL MITOCHONDRIAL-DNA NEAR ITS ORIGIN OF REPLICATION [J].