Ifosfamide-Induced Encephalopathy and Movement Disorder

被引：26

作者：

Ames, Bethany ^{[1
]}

Lewis, Lionel D. ^{[1
]}

Chaffee, Sara ^{[1
]}

Kim, Julie ^{[1
]}

Morse, Richard ^{[1
]}

机构：

[1] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03756 USA

来源：

PEDIATRIC BLOOD & CANCER | 2010年 / 54卷 / 04期

关键词：

encephalopathy; hemiballism; ifosfamide; movement disorder; NERVOUS-SYSTEM TOXICITY; METHYLENE-BLUE; CANCER; MANAGEMENT; THIAMINE;

D O I：

10.1002/pbc.22361

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Ifosfamide is a widely used chemotherapeutic agent for the treatment of a broad spectrum of solid tumors CNS toxicity is a well-described side effect of ifosfamide, but the mechanism of ifosfamide-induced neurotoxicity remains poorly defined We present two pediatric cases of hemiballismic limb movements in the setting of ifosfamide-associated encephalopathy. To our knowledge, there have been no prior reports of ifosfamide-induced hemiballism in pediatric patients. One of our patient's encephalopathy and abnormal movements may have improved after the administration of methylene blue and thramine. Pediatr Blood Cancer 2010,54 624-626 (C) 2009 Wiley-Liss, Inc

引用

页码：624 / 626

页数：3

共 17 条

[1]

Ifosfamide encephalopathy [J].