Mice intradermally-inoculated with the intact lipopolysaccharide, but not the lipid A or O-chain, from Francisella tularensis LVS rapidly acquire varying degrees of enhanced resistance against systemic or aerogenic challenge with virulent strains of the pathogen

被引：26

作者：

Conlan, JW ^{[1
]}

Vinogradov, E ^{[1
]}

Monteiro, MA ^{[1
]}

Perry, MB ^{[1
]}

机构：

[1] Natl Res Council Canada, Inst Biol Sci, Ottawa, ON K1A OR6, Canada

来源：

MICROBIAL PATHOGENESIS | 2003年 / 34卷 / 01期

关键词：

Francisella tularensis; lipopolysaccharide; aerosol; host defense;

D O I：

10.1016/S0882-4010(02)00194-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present study examines the relationship between the structure and important biological effects of the lipopolysaccharide (LPS) of the intracellular bacterial pathogen, Francisella tularensis LVS. It shows that treating mice with sub-immunogenic amounts of intact F. tularensis LPS rapidly induces an enhanced resistance to intradermal or aerogenic challenge with strains of the pathogen of varying virulence. However, neither the free Lipid A nor core-O-chain produced by mild acid hydrolysis of LPS appeared able to elicit this host defense mechanism. Crown Copyright (C) 2003 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：39 / 45

页数：7

共 25 条

[1] A SIMPLE AND RAPID METHOD FOR THE PERMETHYLATION OF CARBOHYDRATES [J].

CIUCANU, I ;

KEREK, F .

CARBOHYDRATE RESEARCH, 1984, 131 (02) :209-217

[2] EARLY PATHOGENESIS OF INFECTION IN THE LIVER WITH THE FACULTATIVE INTRACELLULAR BACTERIA LISTERIA-MONOCYTOGENES, FRANCISELLA-TULARENSIS, AND SALMONELLA-TYPHIMURIUM INVOLVES LYSIS OF INFECTED HEPATOCYTES BY LEUKOCYTES [J].

CONLAN, JW ;

NORTH, RJ .

INFECTION AND IMMUNITY, 1992, 60 (12) :5164-5171

[3] Different host defences are required to protect mice from primary systemic vs pulmonary infection with the facultative intracellular bacterial pathogen, Francisella tularensis LVS [J].

Conlan, JW ;

KuoLee, R ;

Shen, H ;

Webb, A .

MICROBIAL PATHOGENESIS, 2002, 32 (03) :127-134

[4] CD4(+) AND CD8(+) T-CELL-DEPENDENT AND T-CELL-INDEPENDENT HOST-DEFENSE MECHANISMS CAN OPERATE TO CONTROL AND RESOLVE PRIMARY AND SECONDARY FRANCISELLA-TULARENSIS LVS INFECTION IN MICE [J].

CONLAN, JW ;

SJOSTEDT, A ;

NORTH, RJ .

INFECTION AND IMMUNITY, 1994, 62 (12) :5603-5607

[5] Purified lipopolysaccharide from Francisella tularensis live vaccine strain (LVS) induces protective immunity against LVS infection that requires B cells and gamma interferon [J].

Dreisbach, VC ;

Cowley, S ;

Elkins, KL .

INFECTION AND IMMUNITY, 2000, 68 (04) :1988-1996

[6] T-CELL-INDEPENDENT RESISTANCE TO INFECTION AND GENERATION OF IMMUNITY TO FRANCISELLA-TULARENSIS [J].

ELKINS, KL ;

RHINEHARTJONES, T ;

NACY, CA ;

WINEGAR, RK ;

FORTIER, AH .

INFECTION AND IMMUNITY, 1993, 61 (03) :823-829

[7] AEROSOL INFECTION OF ANIMALS WITH STRAINS OF LEGIONELLA-PNEUMOPHILA OF DIFFERENT VIRULENCE - COMPARISON WITH INTRAPERITONEAL AND INTRANASAL ROUTES OF INFECTION [J].

FITZGEORGE, RB ;

BASKERVILLE, A ;

BROSTER, M ;

HAMBLETON, P ;

DENNIS, PJ .

JOURNAL OF HYGIENE, 1983, 90 (01) :81-89

[8]

FORTIER AH, 1996, VACCINE RES, V5, P193

[9] Role of antibody to lipopolysaccharide in protection against low- and high-virulence strains of Francisella tularensis [J].

Fulop, M ;

Mastroeni, P ;

Green, M ;

Titball, RW .

VACCINE, 2001, 19 (31) :4465-4472

[10] Protective effect of β-glucan against systemic Streptococcus pneumoniae infection in mice [J].

Hetland, G ;

Ohno, N ;

Aaberge, IS ;

Lovik, M .

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2000, 27 (02) :111-116

← 1 2 3 →