T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching

被引:194
作者
Toellner, KM [1 ]
Luther, SA
Sze, DMY
Choy, RKW
Taylor, DR
MacLennan, ICM
Acha-Orbea, H
机构
[1] Univ Birmingham, Sch Med, Dept Immunol, Birmingham B15 2TT, W Midlands, England
[2] Ludwig Inst Canc Res, Lausanne Branch, CH-1066 Epalinges, Switzerland
[3] Univ Lausanne, Inst Biochem, CH-1066 Epalinges, Switzerland
关键词
D O I
10.1084/jem.187.8.1193
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The respective production of specific immunoglobulin (Ig)G2a or IgG1 within 5 d of primary immunization with Swiss type mouse mammary tumor virus [MMTV(SW)I or haptenated protein provides a model for the development of T helper 1 (Th1) and Th2 responses. The antibody-producing cells arise from cognate T cell B cell interaction, revealed by the respective induction of C gamma 2a and C gamma 1 switch transcript: production, on the third day after immunization. T cell proliferation and upregulation of mRNA for interferon gamma in response to MMTV(SW) and interleukin 4 in response to haptenated protein also stares during this day. It follows that there is minimal delay in these responses between T cell priming and the onset of cognate interaction between T and B cells leading to class switching and exponential growth. The Th1 or Th2 profile is at least partially established at the time of the first cognate T cell interaction with B cells in the T zone. The addition of killed Bordetella pertussis to the hapten-protein induces nonhapten-specific IgG2a and IgG1 plasma cells, whereas the anti-hapten response continues to be IgG1 dominated. This indicates that a Th2. response to hapten-protein can proceed in a node where there is substantial Th1 activity.
引用
收藏
页码:1193 / 1204
页数:12
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