T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching
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Toellner, KM
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Univ Birmingham, Sch Med, Dept Immunol, Birmingham B15 2TT, W Midlands, EnglandUniv Birmingham, Sch Med, Dept Immunol, Birmingham B15 2TT, W Midlands, England
Toellner, KM
[1
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Luther, SA
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机构:Univ Birmingham, Sch Med, Dept Immunol, Birmingham B15 2TT, W Midlands, England
Luther, SA
Sze, DMY
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机构:Univ Birmingham, Sch Med, Dept Immunol, Birmingham B15 2TT, W Midlands, England
Sze, DMY
Choy, RKW
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机构:Univ Birmingham, Sch Med, Dept Immunol, Birmingham B15 2TT, W Midlands, England
Choy, RKW
Taylor, DR
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机构:Univ Birmingham, Sch Med, Dept Immunol, Birmingham B15 2TT, W Midlands, England
Taylor, DR
MacLennan, ICM
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机构:Univ Birmingham, Sch Med, Dept Immunol, Birmingham B15 2TT, W Midlands, England
MacLennan, ICM
Acha-Orbea, H
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机构:Univ Birmingham, Sch Med, Dept Immunol, Birmingham B15 2TT, W Midlands, England
Acha-Orbea, H
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[1] Univ Birmingham, Sch Med, Dept Immunol, Birmingham B15 2TT, W Midlands, England
[2] Ludwig Inst Canc Res, Lausanne Branch, CH-1066 Epalinges, Switzerland
The respective production of specific immunoglobulin (Ig)G2a or IgG1 within 5 d of primary immunization with Swiss type mouse mammary tumor virus [MMTV(SW)I or haptenated protein provides a model for the development of T helper 1 (Th1) and Th2 responses. The antibody-producing cells arise from cognate T cell B cell interaction, revealed by the respective induction of C gamma 2a and C gamma 1 switch transcript: production, on the third day after immunization. T cell proliferation and upregulation of mRNA for interferon gamma in response to MMTV(SW) and interleukin 4 in response to haptenated protein also stares during this day. It follows that there is minimal delay in these responses between T cell priming and the onset of cognate interaction between T and B cells leading to class switching and exponential growth. The Th1 or Th2 profile is at least partially established at the time of the first cognate T cell interaction with B cells in the T zone. The addition of killed Bordetella pertussis to the hapten-protein induces nonhapten-specific IgG2a and IgG1 plasma cells, whereas the anti-hapten response continues to be IgG1 dominated. This indicates that a Th2. response to hapten-protein can proceed in a node where there is substantial Th1 activity.