The Medical Research Council trials in adult acute lymphocytic leukemia

被引：37

作者：

Durrant, IJ

Richards, SM

Prentice, HG

Goldstone, AH

机构：

[1] Radcliffe Infirm, Clin Trial Serv Unit, Oxford OXZ 6HE, England

[2] Radcliffe Infirm, Epidemiol Studies Unit, Oxford OXZ 6HE, England

[3] UCL Royal Free & Univ Coll Sch Med, London, England

[4] Univ Coll Hosp Natl Hlth Serv Trust, London, England

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2000年 / 14卷 / 06期

关键词：

D O I：

10.1016/S0889-8588(05)70189-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This articles summarizes the history of Medical Research Council (MRC) acute lymphocytic leukemia (ALL) trials in adults. It includes details of the early trials UKALL I-V in which children and adults were entered. UKALL IX, XA, and XII are for those older than 15 years of age (UKALL XII has an upper age limit of 55 years). The trials are all randomized controlled trials. The treatment schedules and survival curves are shown and discussed. A total of 2565 adults were entered between 1970 and 2000, and outcomes for all of these patients are described.

引用

页码：1327 / +

页数：27

共 30 条

[1] BACCARANI M, 1982, BLOOD, V60, P677
[2] BARRETT AJ, 1989, BLOOD, V74, P862
[3] BONE-MARROW TRANSPLANTATION FOR ACUTE LYMPHOBLASTIC-LEUKEMIA
BARRETT, AJ
KENDRA, JR
LUCAS, CF
JOSS, DV
JOSHI, R
DESAI, M
JONES, KH
PHILLIPS, RH
ROGERS, TR
TABARA, Z
WILLIAMSON, S
HOBBS, JR
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1982, 52 (02) : 181 - 188
[4] BLOOMFIELD CD, 1986, BLOOD, V67, P415
[5] The impact of age on outcome in lymphoblastic leukaemia; MRC UKALL X and XA compared: a report from the MRC Paediatric and Adult Working Parties
Chessells, JM
Hall, E
Prentice, HG
Durrant, J
Bailey, CC
Richards, SM
[J]. LEUKEMIA, 1998, 12 (04) : 463 - 473
[6] MEDICAL-RESEARCH COUNCIL LEUKEMIA TRIAL - UKALL V - AN ATTEMPT TO REDUCE THE IMMUNOSUPPRESSIVE EFFECTS OF THERAPY IN CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA
CHESSELLS, JM
DURRANT, J
HARDY, RM
RICHARDS, S
[J]. JOURNAL OF CLINICAL ONCOLOGY, 1986, 4 (12) : 1758 - 1764
[7] CHESSELLS JM, 1984, J CLIN ONCOL, V14, P1758
[8] PROGNOSTIC IMPORTANCE OF MYELOSUPPRESSION DURING MAINTENANCE TREATMENT OF LYMPHOBLASTIC-LEUKEMIA
DOLAN, G
LILLEYMAN, JS
RICHARDS, SM
[J]. ARCHIVES OF DISEASE IN CHILDHOOD, 1989, 64 (09) : 1231 - 1234
[9] Intensification of treatment for adults with acute lymphoblastic leukaemia: results of UK Medical Research Council randomized trial UKALL XA
Durrant, IJ
Prentice, HG
Richards, SM
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1997, 99 (01) : 84 - 92
[10] RESULTS OF MEDICAL-RESEARCH-COUNCIL TRIAL UKALL IX IN ACUTE LYMPHOBLASTIC-LEUKEMIA IN ADULTS - REPORT FROM THE MEDICAL-RESEARCH-COUNCIL WORKING PARTY ON ADULT LEUKEMIA
DURRANT, IJ
RICHARDS, SM
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1993, 85 (01) : 84 - 92

← 1 2 3 →