Knowledge about transplantation tolerance gained in primates

被引：34

作者：

Knechtle, SJ ^{[1
]}

机构：

[1] Univ Wisconsin Hosp, Dept Surg, Madison, WI 53792 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(00)00137-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Research in transplantation tolerance relies on application of successful strategies in a nonhuman-primate organ transplant model for preclinical testing. Three principal approaches are being evaluated: hematopoietic chimerism, lymphocyte depletion and costimulation blockade. Interactive work in these three areas has yielded much new information on mechanisms of tolerance and opened the door to pilot clinical trials. Clinical application of xenotransplantation is likely to depend on such strategies.

引用

页码：552 / 556

页数：5

共 41 条

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