Regulation of cell death by sphingosine 1-phosphate lyase

被引：6

作者：

Colie, Sandra ^{[1
,2
]}

Codogno, Patrice ^{[3
]}

Levade, Thierry ^{[1
,2
]}

Andrieu-Abadie, Nathalie ^{[1
,2
]}

机构：

[1] Fac Med Toulouse, INSERM, U858, F-31073 Toulouse, France

[2] Univ Toulouse 3, Inst Med Mol Rangueil, IFR150, F-31062 Toulouse, France

[3] INSERM, U756, Chatenay Malabry, France

来源：

AUTOPHAGY | 2010年 / 6卷 / 03期

关键词：

sphingosine 1-phosphate lyase; sphingosine; 1-phosphate; apoptosis; autophagy; Bcl-2; starvation; endoplasmic reticulum;

D O I：

10.4161/auto.6.3.11529

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

By controlling sphingosine 1-phosphate (S1P) catabolism, S1P lyase (SPL) represents an undeniable candidate as potential regulator of a cancer cell's fate in response to stress. Our recent study reveals that complete loss of SPL activity leads to upregulation of the antiapoptotic proteins Bcl-2 and Bcl-x(L) and consequently protects against apoptosis induced by chemotherapy and nutrient starvation but not against autophagy. Here, we speculate on how S1P and disruption of S1P breakdown may regulate cell death and autophagy.

引用

页码：426 / 427

页数：2