New genes in alkaloid metabolism and transport

被引：53

作者：

Hashimoto, T ^{[1
]}

Yamada, Y ^{[1
]}

机构：

[1] Nara Inst Sci & Technol, Grad Sch Biol Sci, Nara 6300192, Japan

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2003年 / 14卷 / 02期

关键词：

D O I：

10.1016/S0958-1669(03)00027-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The biosynthetic pathway of plant alkaloids is composed of several distinct enzymes of varying substrate specificities. Homology-based cloning of candidate genes and their subsequent functional testing in heterologous expression systems are accelerating the pace at which the gene catalogues of alkaloid biosynthesis are expanding. Availability of diverse genes involved in the biosynthesis, catabolism, transport, and regulation of pharmaceutically important alkaloids should steadily advance our molecular understanding of alkaloid biology and will enable us to devise more rational strategies for metabolic engineering.

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页码：163 / 168

页数：6

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