Scutellaria baicalensis, a herbal medicine: Anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines

被引：117

作者：

Kumagai, Takashi

Muller, Claudia I.

Desmond, Julian C.

Imai, Yasufumi

Heber, David

Koeffler, H. Phillip

机构：

[1] Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol Oncol, Los Angeles, CA 90048 USA

[2] Univ Calif Los Angeles, Ctr Human Nutr, Los Angeles, CA 90024 USA

[3] Ohme Municipal Gen Hosp, Dept Hematol, Tokyo, Japan

来源：

LEUKEMIA RESEARCH | 2007年 / 31卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Scutellaria baicalensis; ALL; lymphoma; myeloma; baicalin; apoptosis; cell cycle arrest; mitochondria;

D O I：

10.1016/j.leukres.2006.08.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Scutellariabaicalensis (S.B.) is a widely used Chinese herbal medicine. We initially investigated its in vitro anti-tumor activities. S.B. inhibited the growth of ALL, lymphoma and myeloma cell lines by inducing apoptosis and cell cycle arrest at clinically achievable concentrations. The anti-proliferative effect was associated with mitochondrial damage, modulation of the Bcl family of genes, increased level of the CDK inhibitor p27(KIPI) and decreased level of c-myc oncogene. HPLC analysis of S.B. showed it contains 21% baicalin and further studies confirmed it was the major anti-cancer component of S.B. Thus, Scutellaria baicalensis should be tested in clinical trials for these hematopoietic malignancies. (c) 2006 Elsevier Ltd. All rights reserved.

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页码：523 / 530

页数：8

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