Thymic output: a bad TREC record

被引：130

作者：

Hazenberg, MD ^{[1
]}

Borghans, JAM

de Boer, RJ

Miedema, F

机构：

[1] CLB, Dept Clin Viroimmunol, Sanquin Res, Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Landsteiner Lab, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Utrecht, Utrecht, Netherlands

[4] Univ Amsterdam, Acad Med Ctr, Dept Human Retrovirol, NL-1105 AZ Amsterdam, Netherlands

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 02期

关键词：

D O I：

10.1038/ni0203-97

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

TREC assays are used to detect recent thymic emigrants and quantitate thymic output. However, the longevity of naive T cells combined with T cell division suggest TREC data should be interpreted with caution.

引用

页码：97 / 99

页数：3

共 16 条

[1] T cell dynamics in HIV-1 infection
Clark, DR
De Boer, RJ
Wolthers, KC
Miedema, F
[J]. ADVANCES IN IMMUNOLOGY, VOL 73, 1999, 73 : 301 - 327
[2] Changes in thymic function with age and during the treatment of HIV infection
Douek, DC
McFarland, RD
Keiser, PH
Gage, EA
Massey, JM
Haynes, BF
Polis, MA
Haase, AT
Feinberg, MB
Sullivan, JL
Jamieson, BD
Zack, JA
Picker, LJ
Koup, RA
[J]. NATURE, 1998, 396 (6712) : 690 - 695
[3] Evidence for increased T cell turnover and decreased thymic output in HIV infection
Douek, DC
Betts, MR
Hill, BJ
Little, SJ
Lempicki, R
Metcalf, JA
Casazza, J
Yoder, C
Adelsberger, JW
Stevens, RA
Baseler, MW
Keiser, P
Richman, DD
Davey, RT
Koup, RA
[J]. JOURNAL OF IMMUNOLOGY, 2001, 167 (11) : 6663 - 6668
[4] Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution
Douek, DC
Vescio, RA
Betts, MR
Brenchley, JM
Hill, BJ
Zhang, L
Berenson, JR
Collins, RH
Koup, RA
[J]. LANCET, 2000, 355 (9218) : 1875 - 1881
[5] Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection
Haynes, BF
Hale, LP
Weinhold, KJ
Patel, DD
Liao, HX
Bressler, PB
Jones, DM
Demarest, JF
Gebhard-Mitchell, K
Haase, AT
Bartlett, JA
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (04) : 453 - 460
[6] T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events
Hazenberg, MD
Otto, SA
de Pauw, ES
Roelofs, H
Fibbe, WE
Hamann, D
Miedema, F
[J]. BLOOD, 2002, 99 (09) : 3449 - 3453
[7] T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART)
Hazenberg, MD
Stuart, JWTC
Otto, SA
Borleffs, JCC
Boucher, CAB
de Boer, RJ
Miedema, F
Hamann, D
[J]. BLOOD, 2000, 95 (01) : 249 - 255
[8] Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection
Hazenberg, MD
Otto, SA
Stuart, JWTC
Verschuren, MCM
Borleffs, JCC
Boucher, CAB
Coutinho, RA
Lange, JMA
De Wit, TFR
Tsegaye, A
Van Dongen, JJM
Hamann, D
De Boer, RJ
Miedema, F
[J]. NATURE MEDICINE, 2000, 6 (09) : 1036 - 1042
[9] Generation of functional thymocytes in the human adult
Jamieson, BD
Douek, DC
Killian, S
Hultin, LE
Scripture-Adams, DD
Giorgi, JV
Marelli, D
Koup, RA
Zack, JA
[J]. IMMUNITY, 1999, 10 (05) : 569 - 575
[10] T cell homeostasis in patients with rheumatoid arthritis
Koetz, K
Bryl, E
Spickschen, K
O'Fallon, WM
Goronzy, JJ
Weyand, CM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (16) : 9203 - +

← 1 2 →