Siglecs and their roles in the immune system

被引：1566

作者：

Crocker, Paul R. ^{[1
]}

Paulson, James C.

Varki, Ajit

机构：

[1] Univ Dundee, Coll Life Sci, Wellcome Trust Bioctr, Dundee DD15EH, Scotland

[2] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

[4] Univ Calif San Diego, Glycobiol Res & Training Ctr, Dept Med, La Jolla, CA 92093 USA

[5] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 04期

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

IMMUNOGLOBULIN-LIKE LECTINS; ACID-BINDING-RECEPTOR; PLASMACYTOID DENDRITIC CELLS; TYROSINE PHOSPHATASES SHP-1; MYELOID-LEUKEMIA CELLS; NATURAL-KILLER-CELLS; SURFACE SIALIC ACIDS; INHIBITORY RECEPTOR; B-CELLS; SELECTIVE RECOGNITION;

D O I：

10.1038/nri2056

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cell surfaces in the immune system are richly equipped with a complex mixture of glycans, which can be recognized by diverse glycan-binding proteins. The Siglecs are a family of sialic-acid-binding immunoglobulin-like lectins that are thought to promote cell-cell interactions and regulate the functions of cells in the innate and adaptive immune systems through glycan recognition. In this Review, we describe recent studies on signalling mechanisms and discuss the potential role of Siglecs in triggering endocytosis and in pathogen recognition. Finally, we discuss the postulated functions of the recently discovered CD33-related Siglecs and consider the factors that seem to be driving their rapid evolution.

引用

页码：255 / 266

页数：12

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