Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage

被引：326

作者：

Mori, K. ^{[1
]}

Nakao, K. ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Med & Clin Sci, Sakyo Ku, Kyoto 6068507, Japan

来源：

KIDNEY INTERNATIONAL | 2007年 / 71卷 / 10期

关键词：

progression of renal failure; development; iron; siderophore; mesenchymal-epithelial transition; ischemia-reperfusion; gene expression;

D O I：

10.1038/sj.ki.5002165

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Neutrophil gelatinase-associated lipocalin (Ngal, 24p3, SIP24, lipocalin 2, or siderocalin) was originally purified from neutrophils, but with unknown function. Recently, it was identified that Ngal activates nephron formation in the embryonic kidney, is rapidly and massively induced in renal failure and possesses kidney-protective activity. We would like to propose that blood, urine, and kidney Ngal levels are the real-time indicators of active kidney damage, rather than one of many markers of functional nephron number (as Forest Fire Theory). Ngal is a novel iron-carrier protein exerting pleiotropic actions including the upregulation of epithelial marker E-cadherin expression, opening an exciting field in cell biology.

引用

页码：967 / 970

页数：4

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