Control of VSG gene expression sites in Trypanosoma brucei

被引：65

作者：

Borst, P ^{[1
]}

Bitter, W ^{[1
]}

Blundell, PA ^{[1
]}

Chaves, I ^{[1
]}

Cross, M ^{[1
]}

Gerrits, H ^{[1
]}

van Leeuwen, F ^{[1
]}

McCulloch, R ^{[1
]}

Taylor, M ^{[1
]}

Rudenko, G ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Mol Biol, NL-1066 CX Amsterdam, Netherlands

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1998年 / 91卷 / 01期

基金：

英国惠康基金;

关键词：

expression site; Trypanosoma brucei; modified base; J; transferrin receptor; antigenic variation;

D O I：

10.1016/S0166-6851(97)00184-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antigenic variation in African trypanosomes continues to be one of the most elaborate and intriguing strategies ever devised by a protozoan parasite to avoid complete destruction by the immune defense of its mammalian host. Here we review some of the recent advances in our understanding of this strategy, concentrating on (unpublished) work from our laboratory. (C) 1998 Francqui Foundation. Published by Elsevier Science B.V. All rights reserved.

引用

页码：67 / 76

页数：10

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