PACAP stimulates dopamine neuronal activity in the medial basal hypothalamus and inhibits prolactin

被引：18

作者：

Anderson, ST ^{[1
]}

Curlewis, JD ^{[1
]}

机构：

[1] Univ Queensland, Dept Physiol & Pharmacol, Brisbane, Qld 4072, Australia

来源：

BRAIN RESEARCH | 1998年 / 790卷 / 1-2期

基金：

澳大利亚研究理事会;

关键词：

PACAP; prolactin; DOPAC; microdialysis; TIDA neuron; sheep;

D O I：

10.1016/S0006-8993(98)00176-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In sheep intracerebroventricular injection of PACAP (10 nmol) significantly (P < 0.01) stimulated the levels of the dopamine metabolite DOPAC within the medial basal hypothalamus las measured by in vivo microdialysis) and this effect was temporally correlated with a significant (P < 0.05) suppression in peripheral prolactin concentrations. This result is in accord with the hypothesis that PACAP suppresses prolactin secretion from the anterior pituitary gland by stimulating dopamine release from tuberoinfundibular dopaminergic neurons. (C) 1998 Elsevier Science B.V.

引用

页码：343 / 346

页数：4

共 18 条

[1] Pituitary adenylate cyclase-activating polypeptide acts within the medial basal hypothalamus to inhibit prolactin and luteinizing hormone secretion [J].

Anderson, ST ;

Sawangjaroen, K ;

Curlewis, JD .

ENDOCRINOLOGY, 1996, 137 (08) :3424-3429

[2] A method for drug infusion into the lateral median eminence and arcuate nucleus of sheep [J].

Anderson, ST ;

Sawangjaroen, K ;

Curlewis, JD .

JOURNAL OF NEUROSCIENCE METHODS, 1997, 71 (02) :169-176

[3] A FACTOR(S) FROM A TROPHOBLAST CELL-LINE INCREASES TYROSINE-HYDROXYLASE ACTIVITY IN FETAL HYPOTHALAMIC CELL-CULTURES [J].

ARBOGAST, LA ;

SOARES, MJ ;

ROBERTSON, MC ;

VOOGT, JL .

ENDOCRINOLOGY, 1993, 133 (01) :111-120

[4] PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) INCREASES PROLACTIN-RELEASE AND TUBEROINFUNDIBULAR DOPAMINERGIC NEURONAL-ACTIVITY [J].

ARBOGAST, LA ;

VOOGT, JL .

BRAIN RESEARCH, 1994, 655 (1-2) :17-24

[5] PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDE (PACAP) AND ITS RECEPTORS - NEUROENDOCRINE AND ENDOCRINE INTERACTION [J].

ARIMURA, A ;

SHIODA, S .

FRONTIERS IN NEUROENDOCRINOLOGY, 1995, 16 (01) :53-88

[6] GENE-EXPRESSION OF PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDE (PACAP) IN THE RAT HYPOTHALAMUS [J].

HANNIBAL, J ;

MIKKELSEN, JD ;

CLAUSEN, H ;

HOLST, JJ ;

WULFF, BS ;

FAHRENKRUG, J .

REGULATORY PEPTIDES, 1995, 55 (02) :133-148

[7] Stimulatory effects of vasoactive intestinal peptide and pituitary adenylate cyclase-activating peptide on tuberoinfundibular dopaminergic neuron activity in estrogen-treated ovariectomized rats and their correlation with prolactin secretion [J].

Huang, SK ;

Pan, JT .

NEUROENDOCRINOLOGY, 1996, 64 (03) :208-214

[8] CONTRASTING EFFECTS OF PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDE (PACAP) ON INVIVO AND INVITRO PROLACTIN AND GROWTH-HORMONE RELEASE IN MALE-RATS [J].

JARRY, H ;

LEONHARDT, S ;

SCHMIDT, WE ;

CREUTZFELDT, W ;

WUTTKE, W .

LIFE SCIENCES, 1992, 51 (11) :823-830

[9]

LEONHARDT S, 1992, NEUROENDOCRINOL LETT, V14, P319

[10] ISOLATION OF A NOVEL-38 RESIDUE-HYPOTHALAMIC POLYPEPTIDE WHICH STIMULATES ADENYLATE-CYCLASE IN PITUITARY-CELLS [J].

MIYATA, A ;

ARIMURA, A ;

DAHL, RR ;

MINAMINO, N ;

UEHARA, A ;

JIANG, L ;

CULLER, MD ;

COY, DH .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 164 (01) :567-574

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