Prevention of congenital toxoplasmosis

被引:34
作者
Foulon, W
Naessens, A
Ho-Yen, D
机构
[1] Free Univ Brussels, Akad Ziekenhuis, Dept Obstet, B-1090 Brussels, Belgium
[2] Free Univ Brussels, Akad Ziekenhuis, Dept Microbiol, B-1090 Brussels, Belgium
[3] Scottish Toxoplasma Reference Lab, Dept Microbiol, Inverness, Scotland
关键词
congenital toxoplasmosis; neonatal screening; prenatal screening; prevention;
D O I
10.1515/JPM.2000.043
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
In utero infection with Toxoplasma gondii may result in congenital defects such as hydrocephalus, chorioretinitis and mental retardation; these defects may be present at birth or may develop later in life. Prevention of this disease can be achieved in different ways. The most effective measure is to prevent the acquisition of the disease during pregnancy by avoiding risk factors for Toxoplasma gondii infection. Health education may decrease the incidence of toxoplasmosis during pregnancy by 60 %. A second preventive measure is based on serologic screening during pregnancy to identify infected women. Treatment during pregnancy results in a significant reduction in the incidence of sequelae including severe handicaps. A third possible intervention is treating infected neonates. Antibiotic treatment of infected children has a beneficial effect on the development of sequelae and the sooner therapy is started after birth, the better the outcome. This overview presents the potential benefits and harms of these different options available for the prevention of congenital toxoplasmosis.
引用
收藏
页码:337 / 345
页数:9
相关论文
共 43 条
[1]  
Ancelle T., 1996, Bulletin Epidemiologique Hebdomadaire, P227
[2]  
ASPOCK H, 1992, SCAND J INFECT DIS, P32
[3]  
ASPOCK H, 2000, CONGENITAL TOXOPLASM
[4]  
*CDC, 1987, MMWR-MORBID MORTAL W, V36, P664
[5]   PRENATAL MANAGEMENT OF 746 PREGNANCIES AT RISK FOR CONGENITAL TOXOPLASMOSIS [J].
DAFFOS, F ;
FORESTIER, F ;
CAPELLAPAVLOVSKY, M ;
THULLIEZ, P ;
AUFRANT, C ;
VALENTI, D ;
COX, WL .
NEW ENGLAND JOURNAL OF MEDICINE, 1988, 318 (05) :271-275
[6]   CONGENITAL TOXOPLASMOSIS - PROSPECTIVE STUDY OF 378 PREGNANCIES [J].
DESMONTS, G ;
COUVREUR, J .
NEW ENGLAND JOURNAL OF MEDICINE, 1974, 290 (20) :1110-1116
[7]  
DONALDSON MDC, 1998, SEMIN NEONATOL, V3, P35
[8]  
Dubey J. P., 1988, TOXOPLASMOSIS ANIMAL
[9]  
Flamm H, 1981, Padiatr Grenzgeb, V20, P27
[10]   PRENATAL-DIAGNOSIS OF CONGENITAL TOXOPLASMOSIS [J].
FOULON, W ;
NAESSENS, A ;
MAHLER, T ;
DEWAELE, M ;
DECATTE, L ;
DEMEUTER, F .
OBSTETRICS AND GYNECOLOGY, 1990, 76 (05) :769-772