TARPs and the AMPA receptor trafficking paradox

被引：112

作者：

Ziff, Edward B. ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Biochem, New York, NY 10016 USA

来源：

NEURON | 2007年 / 53卷 / 05期

关键词：

D O I：

10.1016/j.neuron.2007.02.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

AMPA receptors (AMPARs) conduct fast, excitatory currents that depolarize neurons and trigger action potentials. AMPARs took on new importance when it was shown that AMPAR transport can increase or decrease the number of AMPARs at synapses and give rise to synapse plasticity, including long-term potentiation (LTP) and long-term depression (LTD). This review considers how transmembrane AMPAR regulatory proteins (TARPs), a novel family of AMPAR auxiliary subunits, have changed our view of AMPAR transport and raised some perplexing questions.

引用

收藏

页码：627 / 633

页数：7

相关论文

共 57 条

[1] Functional assembly of AMPA and kainate receptors is mediated by several discrete protein-protein interactions [J].

Ayalon, G ;

Stern-Bach, Y .

NEURON, 2001, 31 (01) :103-113

[2] Receptor trafficking and the plasticity of excitatory synapses [J].

Barry, MF ;

Ziff, EB .

CURRENT OPINION IN NEUROBIOLOGY, 2002, 12 (03) :279-286

[3] The interaction between stargazin and PSD-95 regulates AMPA receptor surface trafficking [J].

Bats, Cecile ;

Groc, Laurent ;

Choquet, Daniel .

NEURON, 2007, 53 (05) :719-734

[4] Different domains of the AMPA receptor direct stargazin-mediated trafficking and stargazin-mediated modulation of kinetics [J].

Bedoukian, Matthew A. ;

Weeks, Autumn M. ;

Partin, Kathryn M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (33) :23908-23921

[5] Synaptic incorporation of AMPA receptors during LTP is controlled by a PKC phosphorylation site on GluR1 [J].

Boehm, Jannic ;

Kang, Myoung-Goo ;

Johnson, Richard C. ;

Esteban, Jose ;

Huganir, Richard L. ;

Malinow, Roberto .

NEURON, 2006, 51 (02) :213-225

[6] Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms [J].

Chen, L ;

Chetkovich, DM ;

Petralia, RS ;

Sweeney, NT ;

Kawasaki, Y ;

Wenthold, RJ ;

Bredt, DS ;

Nicoll, RA .

NATURE, 2000, 408 (6815) :936-943

[7] Impaired cerebellar synapse maturation in waggler, a mutant mouse with a disrupted neuronal calcium channel γ subunit [J].

Chen, L ;

Bao, SW ;

Qiao, XX ;

Thompson, RF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (21) :12132-12137

[8]

Chetkovich DM, 2002, J NEUROSCI, V22, P5791

[9] Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95 [J].

Choi, J ;

Ko, J ;

Park, E ;

Lee, JR ;

Yoon, J ;

Lim, S ;

Kim, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (14) :12359-12363

[10]

Chung HJ, 2000, J NEUROSCI, V20, P7258

← 1 2 3 4 5 6 →