Through the "Gatekeeper Door": Exploiting the Active Kinase Conformation

被引：425

作者：

Zuccotto, Fabio ^{[1
]}

Ardini, Elena ^{[2
]}

Casale, Elena ^{[1
]}

Angiolini, Mauro ^{[3
]}

机构：

[1] Nerviano Med Sci, Dept Chem Core Technol, I-20014 Nerviano, Italy

[2] Nerviano Med Sci, Dept Cell Biol Signal Transduct, I-20014 Nerviano, Italy

[3] Nerviano Med Sci, Dept Med Chem, I-20014 Nerviano, Italy

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 53卷 / 07期

关键词：

SMALL-MOLECULE INHIBITORS; P38 MAP KINASE; TYROSINE KINASE; PROTEIN-KINASES; STRUCTURAL BASIS; LUNG-CANCER; PHARMACOPHORE APPROACH; DOMAIN MUTATIONS; DRUG-RESISTANCE; POTENT;

D O I：

10.1021/jm901443h

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：2681 / 2694

页数：14

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