Aspirin or acetaminophen? A comparison from data collected by the Spanish drug monitoring system

被引:16
作者
Carvajal, A
Prieto, JR
Requejo, AA
Arias, LHM
机构
[1] Castilla y Leon Regl. Ctr. P., Faculty of Medicine, University of Valladolid, Valladolid
[2] Departamento de Farmacología, Facultad de Medicina, 47005 Valladolid, Avda. Ramón y Cajal
关键词
aspirin; acetaminophen; product surveillance; postmarketing; adverse drug reaction reporting systems; drug monitoring; gastrointestinal hemorrhage;
D O I
10.1016/0895-4356(95)00539-0
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
To characterize and compare the toxicity profiles of aspirin and acetaminophen when used by large populations, all records of adverse drug reactions to these drugs reported to the Spanish Drug Monitoring System from 1982 to 1991 were analyzed. According to these data, aspirin induced reactions were more serious than those reactions to acetaminophen; the severity of all the reactions in both cases was associated with time of exposure and with the accumulated dose administered. For GI reactions to aspirin no association was found between severity and time of exposure or dose, although an association with age was found. There were no differences between the proportions of deaths, malformations, and renal damage recorded for either of the two groups. Proportions of hematological and hepatic disturbances were greater with acetaminophen. Adverse drug reaction data for aspirin and acetaminophen from spontaneous reporting seem to be consistent with data coming from observational studies.
引用
收藏
页码:255 / 261
页数:7
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