Identification of autoxidation and photodegradation products of ethynylestradiol by on-line HPLC-NMR and HPLC-MS

被引：42

作者：

Segmuller, BE ^{[1
]}

Armstrong, BL ^{[1
]}

Dunphy, R ^{[1
]}

Oyler, AR ^{[1
]}

机构：

[1] RW Johnson Pharmaceut Res Inst, Raritan, NJ 08869 USA

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2000年 / 23卷 / 05期

关键词：

ethynylestradiol; estrogen; HPLC-MS; HPLC-NMR; autoxidation; photodegradation;

D O I：

10.1016/S0731-7085(00)00363-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

HPLC-NMR. HPLC-MS, and HPLC-UV were used to characterize the predominant solution autoxidation and photodegradation products of ethynylestradiol (1). A hydroperoxide (2) and a series of isomeric dimeric oxidation products (3-7), were identified. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：927 / 937

页数：11

共 34 条

[1] OXIDATIVE COUPLING OF PHENOLS .9. THE ROLE OF STERIC EFFECTS IN THE OXIDATION OF METHYL-SUBSTITUTED PHENOLS [J].

ARMSTRONG, DR ;

CAMERON, C ;

NONHEBEL, DC ;

PERKINS, PG .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1983, (05) :581-585

[2] OXIDATIVE COUPLING OF PHENOLS .10. THE ROLE OF STERIC EFFECTS IN THE FORMATION OF C-O COUPLED PRODUCTS [J].

ARMSTRONG, DR ;

CAMERON, C ;

NONHEBEL, DC ;

PERKINS, PG .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1983, (05) :587-589

[3] OXIDATIVE COUPLING OF PHENOLS .8. A THEORETICAL-STUDY OF THE COUPLING OF PHENOXYL RADICALS [J].

ARMSTRONG, DR ;

CAMERON, C ;

NONHEBEL, DC ;

PERKINS, PG .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1983, (05) :575-579

[4] OXIDATIVE COUPLING OF PHENOLS .7. SPIN-DENSITY CALCULATIONS ON THE PHENOXYL RADICAL [J].

ARMSTRONG, DR ;

CAMERON, C ;

NONHEBEL, DC ;

PERKINS, PG .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1983, (05) :569-573

[5] OXIDATIVE COUPLING OF PHENOLS .6. A STUDY OF THE ROLE OF SPIN-DENSITY FACTORS ON THE PRODUCT COMPOSITION IN THE OXIDATIONS OF 3,5-DIMETHYLPHENOL AND PHENOL [J].

ARMSTRONG, DR ;

CAMERON, C ;

NONHEBEL, DC ;

PERKINS, PG .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1983, (05) :563-568

[6] PHOTOLYSIS AND PHOTO-OXYDATION OF PHENOL IN AQUEOUS-SOLUTION [J].

AUDUREAU, J ;

FILIOL, C ;

BOULE, P ;

LEMAIRE, J .

JOURNAL DE CHIMIE PHYSIQUE ET DE PHYSICO-CHIMIE BIOLOGIQUE, 1976, 73 (06) :613-620

[7]

Bailey NJC, 2000, RAPID COMMUN MASS SP, V14, P679, DOI 10.1002/(SICI)1097-0231(20000430)14:8<679::AID-RCM936>3.0.CO

[8]

2-V

[9] Application of directly coupled HPLC-NMR-MS/MS to the identification of metabolites of 5-trifluoromethylpyridone (2-hydroxy-5-trifluoromethylpyridine) in hydroponically grown plants [J].

Bailey, NJC ;

Cooper, P ;

Hadfield, ST ;

Lenz, EM ;

Lindon, JC ;

Nicholson, JK ;

Stanley, PD ;

Wilson, ID ;

Wright, B ;

Taylor, SD .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2000, 48 (01) :42-46

[10] HPLC-CD on-line coupling in combination with HPLC-NMR and HPLC-MS/MS for the determination of the full absolute stereostructure of new metabolites in plant extracts [J].

Bringmann, G ;

Messer, K ;

Wohlfarth, M ;

Kraus, J ;

Dumbuya, K ;

Rückert, M .

ANALYTICAL CHEMISTRY, 1999, 71 (14) :2678-2686

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